Cooperative kinesin
نویسندگان
چکیده
منابع مشابه
Cooperative kinesin
Cooperative kinesin rain travel might be more efficient if the tracks helped the train along. On page 691, Muto et al. show that, unlike trains, kinesin motors do get a boost from their tracks—in this case, microtubules. Muto and colleagues show that the binding of the plus end–directed motor kinesin to microtubules is cooperative. Like proverbial sheep, once one bead (or motor) bound to a fila...
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Interaction of kinesin-coated latex beads with a single microtubule (MT) was directly observed by fluorescence microscopy. In the presence of ATP, binding of a kinesin bead to the MT facilitated the subsequent binding of other kinesin beads to an adjacent region on the MT that extended for micrometers in length. This cooperative binding was not observed in the presence of ADP or 5'-adenylylimid...
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متن کاملKinesin backsteps.
Kinesin-1 is a walking machine that takes ~8 nm steps along microtubules. Some aspects of the molecular mechanism of walking are now clear, but many are not. In the present paper, we discuss currently controversial points, focusing on the pathways by which kinesin takes occasional backsteps. Backsteps represent failures of the forwards-biasing mechanism. By studying the mechanochemistry of back...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2005
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1685iti1